krishanu saha
Saha K.*, Mei Y.*, Reisterer C.M., Pyzocha N., Yang J., Muffat J., Alexander M.R., Langer R., Anderson D.G. and Jaenisch R. (2011) “Surface-engineered substrates for improved human pluripotent stem cell culture under fully defined conditions.” Proceedings of the National Academy of Sciences of the USA. 108(46), 18714-9. [*equal contribution]
Saha K. and J.B. Hurlbut (2011) “Treat donors as partners in biobank research.” Nature. 478, 312-313.
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Discussed further in Nature and The Scientist.
Mathews D.J.H., Graff G.D., Saha K., Winickoff D.E. (2011) “Access To Stem Cells And Data: Persons, Property Rights, And Scientific Progress.” Science. 331, 725-727.
Saha K. and J.B. Hurlbut (2011) “Disease modeling using pluripotent stem cells: making sense of disease from bench to bedside.” Swiss Medical Weekly. 141.
Hanna J., Saha K., and Jaenisch R. (2010) “Pluripotency and Cellular Reprogramming: Facts, Hypotheses, Unresolved Issues.” Cell. 143(4) 508-525.
Saha K., Kim J., Irwin E., Yoon J., Momin F., Trujillo V., Schaffer D.V., Healy K.E., and R.C. Hayward (2010) “Surface creasing instability of soft polyacrylamide cell culture substrates.” Biophysical Journal. 99(12) L94-L96.
Mei Y.*, Saha K.*, Bogatyrev S., Yang J., Hook A.L., Kalcioglu Z.I., Cho S.W., Mitalipova M., Pyzocha N., Rojas F., van Vliet K.J., Davies M.C., Alexander M.R., Langer R.S., Jaenisch R., and Anderson D.G. (2010) “Combinatorial Development of Biomaterials for Clonal Growth of Human Pluripotent Stem Cells.” Nature Materials. 9, 768-778. [*equal contribution]
Hanna J., Cheng A.W., Saha K., Kim J., Lengner C.J., Soldner F., Cassady J.P., Muffat J., Carey B.W., and Jaenisch R. (2010) “Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs.” Proceedings of the National Academy of Sciences of the USA. 107(20), 9222-9227.
Saha K. and R. Jaenisch (2009) “Technical challenges in using human induced pluripotent stem cells to model disease.” Cell Stem Cell. 5, 584-595.
Hanna J.*, Saha K.*, Pando B., van Zon J., Lengner C.J., Creyghton M.P., van Oudenaarden A., and Jaenisch R. (2009) “Direct cell reprogramming is a stochastic process amenable to acceleration.” Nature. 462, 595-601. [*equal contribution]
Carey B.W., Markoulaki S., Hanna J., Saha K., Gao Q., Mitalipova M., and Jaenisch R. (2009) “Reprogramming of murine and human somatic cells using a single polycistronic vector.” Proceedings of the National Academy of Sciences of the USA. 106(1), 157-162.
Winickoff D.W.*, Saha K.*, and Graff G.* (2009) “Opening Life Sciences Research and Development: Integrative Management of Data, IP and Ethics in Stem Cells” Yale Journal of Health Policy, Law and Ethics. 9(1), 52-127. [*equal contribution]
Saha K., Keung A., Irwin E.F., Li Y., Schaffer D.V. and Healy K.E. (2008) “Substrate modulus directs neural stem cell behavior.” Biophysical Journal. 95(9), 4426-4438.
Irwin E.F., Saha K., Rosenbluth M., Gamble, L.J., Castner D.G., and Healy K.E. (2008) “Modulus-dependent macrophage adhesion and behavior.” Journal of Biomaterial Science: Polymer Edition. 19(10), 1363-1382.
Wall S.T., Saha K., Ashton R.S., Kam K.R., Schaffer D.V. and Healy K.E. (2008) “Multivalency of Sonic hedgehog conjugated to linear polymer chains modulates protein potency.” Bioconjugate Chemistry. 19(4), 806–812.
Saha K.*, Pollock J.F.*, Schaffer D.V., and K.E. Healy. (2007) “Designing synthetic materials to control stem cell phenotype.” Current Opinion in Chemical Biology. 11(4), 381-7. [*equal contribution]
Saha K., Irwin E.F., Kozhukh J., Healy K.E., and D.V. Schaffer (2007) “Biomimetic interfacial interpenetrating polymer networks control neural stem cell behavior.” Journal of Biomedical Materials Research: Part A. 81A:1.
Saha K. and D.V. Schaffer (2006) “Signaling dynamics in Sonic hedgehog tissue patterning.” Development. 133, 889-900.
Saha K., Bender F., Rasmusson A., and E. Gizeli (2003) "Probing the viscoelasticity of protein layers with acoustic waveguide devices." Langmuir. 19(4), 1304-1311.
Saha K., Bender F., and E. Gizeli (2003) "Comparative study of IgG binding to bacterial proteins G and A: Non-equilibrium kinetic binding constant determination with the acoustic waveguide device." Analytical Chemistry. 75(4), 835-842.
Gizeli, E., Bender, F., Rasmusson A., Saha K., Josse F., and R. Cernosek (2003) "Sensitivity of the acoustic waveguide biosensor to protein binding as a function of the device geometry." Biosensors and Bioelectronics. 18(11), 1399-406.
Publications
Working at the frontiers of
stem cell biology and engineering
I am a Society in Science Fellow and currently a postdoc in Rudolf Jaenisch’s group at Whitehead/MIT and Sheila Jasanoff’s program at Harvard University. Broadly speaking, I am interested in emerging human biotechnologies and their use in personalized medicine.
